Drug interactions
Irbesartan + Quinapril
Severity: Major
Irbesartan and Quinapril: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an angiotensin receptor blocker with an ACE inhibitor produces dual renin-angiotensin system blockade. This raises the risk of hypotension, hyperkalemia and acute kidney injury without clear added cardiovascular benefit in most patients.
What this interaction means in plain words
Irbesartan and Quinapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic inhibition of the renin-angiotensin-aldosterone system at two points.
What to do
Avoid the combination in routine practice, especially in diabetic nephropathy or renal impairment. If it is used under specialist direction, monitor potassium, creatinine and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Quinapril?
MediHelp rates the interaction as major. Irbesartan and Quinapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an angiotensin receptor blocker with an ACE inhibitor produces dual renin-angiotensin system blockade. This raises the risk of hypotension, hyperkalemia and acute kidney injury without clear added cardiovascular benefit in most patients.
How serious is the interaction between Irbesartan and Quinapril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in routine practice, especially in diabetic nephropathy or renal impairment. If it is used under specialist direction, monitor potassium, creatinine and blood pressure closely.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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