Drug interactions
Irbesartan + Salicylates
Severity: Moderate
Irbesartan and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates can blunt the blood pressure lowering effect of irbesartan and may reduce renal function. The risk is greatest in older adults, in volume-depleted patients and in those with existing kidney disease. Potassium may also rise.
What this interaction means in plain words
Irbesartan and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandins reduces glomerular perfusion and sodium excretion, opposing angiotensin receptor blockade and adding to renal hemodynamic stress.
What to do
Monitor blood pressure, serum creatinine and potassium when starting or changing salicylate doses, and keep patients well hydrated. Prefer the lowest effective salicylate dose or an alternative analgesic such as paracetamol if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Irbesartan and Salicylates, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Salicylates?
MediHelp rates the interaction as moderate. Irbesartan and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates can blunt the blood pressure lowering effect of irbesartan and may reduce renal function. The risk is greatest in older adults, in volume-depleted patients and in those with existing kidney disease. Potassium may also rise.
How serious is the interaction between Irbesartan and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when starting or changing salicylate doses, and keep patients well hydrated. Prefer the lowest effective salicylate dose or an alternative analgesic such as paracetamol if renal function declines.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
