Drug interactions
Irbesartan + Salsalate
Severity: Moderate
Irbesartan and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate, a salicylate with NSAID-like properties, can reduce the antihypertensive effect of irbesartan and may impair kidney function. Older patients and those who are dehydrated or on diuretics are at greatest risk. Hyperkalemia can also occur.
What this interaction means in plain words
Irbesartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, opposing angiotensin receptor blockade and adding to renal hemodynamic stress.
What to do
Check blood pressure, serum creatinine and potassium within the first weeks of combined use and after dose changes. Ensure adequate hydration and consider an alternative analgesic if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Salsalate?
MediHelp rates the interaction as moderate. Irbesartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate, a salicylate with NSAID-like properties, can reduce the antihypertensive effect of irbesartan and may impair kidney function. Older patients and those who are dehydrated or on diuretics are at greatest risk. Hyperkalemia can also occur.
How serious is the interaction between Irbesartan and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure, serum creatinine and potassium within the first weeks of combined use and after dose changes. Ensure adequate hydration and consider an alternative analgesic if renal function worsens.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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