Drug interactions
Irbesartan + Xipamide
Severity: Moderate
Irbesartan and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic and combining it with irbesartan lowers blood pressure more than either alone, which is often intended. Excessive effect can cause hypotension, volume depletion and reduced renal function, especially at the start of therapy.
What this interaction means in plain words
Irbesartan and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive blood-pressure lowering through diuresis-related volume reduction and renin-angiotensin blockade.
What to do
Monitor blood pressure, electrolytes and creatinine when starting or changing doses. Consider a lower starting dose in volume-depleted or elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Xipamide?
MediHelp rates the interaction as moderate. Irbesartan and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic and combining it with irbesartan lowers blood pressure more than either alone, which is often intended. Excessive effect can cause hypotension, volume depletion and reduced renal function, especially at the start of therapy.
How serious is the interaction between Irbesartan and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, electrolytes and creatinine when starting or changing doses. Consider a lower starting dose in volume-depleted or elderly patients.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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