Drug interactions
Irinotecan + Ivosidenib
Severity: Moderate
Irinotecan and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower irinotecan and SN-38 exposure, potentially reducing efficacy. Magnitude is not well defined.
What this interaction means in plain words
Irinotecan and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irinotecan belongs to Oncology; Ivosidenib belongs to Oncology.
Why it happens
Induction of CYP3A4 increases metabolic clearance of irinotecan.
What to do
Monitor tumour response; consider alternatives if feasible. Ivosidenib labeling advises avoiding sensitive CYP3A4 substrates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Irinotecan with Ivosidenib?
MediHelp rates the interaction as moderate. Irinotecan and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower irinotecan and SN-38 exposure, potentially reducing efficacy. Magnitude is not well defined.
How serious is the interaction between Irinotecan and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumour response; consider alternatives if feasible. Ivosidenib labeling advises avoiding sensitive CYP3A4 substrates.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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