Drug interactions
Irinotecan + Larotrectinib
Severity: Minor
Irinotecan and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and weak inhibitor, and a clinically important effect on irinotecan is unlikely. Any change in irinotecan exposure would be small and of uncertain direction.
What this interaction means in plain words
Irinotecan and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Irinotecan belongs to Oncology; Larotrectinib belongs to Oncology.
Why it happens
Larotrectinib weakly inhibits CYP3A4, which could slightly alter irinotecan oxidative metabolism.
What to do
No routine adjustment is needed. Monitor for the usual irinotecan toxicities.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Irinotecan with Larotrectinib?
MediHelp rates the interaction as minor. Irinotecan and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and weak inhibitor, and a clinically important effect on irinotecan is unlikely. Any change in irinotecan exposure would be small and of uncertain direction.
How serious is the interaction between Irinotecan and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for the usual irinotecan toxicities.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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