Drug interactions
Irinotecan + Netupitant-palonosetron
Severity: Moderate
Irinotecan and Netupitant-palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant inhibits CYP3A4, which metabolizes irinotecan and its active metabolite SN-38 to inactive products. Exposure to irinotecan may rise, potentially increasing diarrhea and myelosuppression. Clinical significance is uncertain, but caution is warranted given the narrow therapeutic index.
What this interaction means in plain words
Irinotecan and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irinotecan belongs to Oncology; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Why it happens
Netupitant inhibits CYP3A4, reducing oxidative clearance of irinotecan.
What to do
Monitor for diarrhea and neutropenia during irinotecan treatment with netupitant and adjust irinotecan per toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Frequently asked questions
Can I take Irinotecan with Netupitant-palonosetron?
MediHelp rates the interaction as moderate. Irinotecan and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Netupitant inhibits CYP3A4, which metabolizes irinotecan and its active metabolite SN-38 to inactive products. Exposure to irinotecan may rise, potentially increasing diarrhea and myelosuppression. Clinical significance is uncertain, but caution is warranted given the narrow therapeutic index.
How serious is the interaction between Irinotecan and Netupitant-palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea and neutropenia during irinotecan treatment with netupitant and adjust irinotecan per toxicity.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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