Drug interactions
Irinotecan + Sotorasib
Severity: Minor
Irinotecan and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib inhibits P-gp and may affect irinotecan or SN-38 transport. Irinotecan is not a sensitive P-gp substrate and the effect is probably small. Sotorasib also induces CYP3A4, which could lower exposure.
What this interaction means in plain words
Irinotecan and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Irinotecan belongs to Oncology; Sotorasib belongs to Oncology.
Why it happens
P-gp inhibition and weak CYP3A4 induction by sotorasib; net effect on irinotecan is not established.
What to do
No routine adjustment; monitor for toxicity and response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Irinotecan with Sotorasib?
MediHelp rates the interaction as minor. Irinotecan and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib inhibits P-gp and may affect irinotecan or SN-38 transport. Irinotecan is not a sensitive P-gp substrate and the effect is probably small. Sotorasib also induces CYP3A4, which could lower exposure.
How serious is the interaction between Irinotecan and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for toxicity and response.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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