Drug interactions
Irinotecan liposomal + Lapatinib
Severity: Moderate
Irinotecan liposomal and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and P-gp, and may increase exposure to irinotecan and its active metabolite. Lapatinib also inhibits UGT1A1, which could raise SN-38 and worsen diarrhea and neutropenia.
What this interaction means in plain words
Irinotecan liposomal and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lapatinib inhibits CYP3A4, P-gp and UGT1A1, altering irinotecan and SN-38 disposition.
What to do
Monitor closely for severe diarrhea and neutropenia and check blood counts; reduce the irinotecan dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Irinotecan liposomal with Lapatinib?
MediHelp rates the interaction as moderate. Irinotecan liposomal and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP3A4 and P-gp, and may increase exposure to irinotecan and its active metabolite. Lapatinib also inhibits UGT1A1, which could raise SN-38 and worsen diarrhea and neutropenia.
How serious is the interaction between Irinotecan liposomal and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for severe diarrhea and neutropenia and check blood counts; reduce the irinotecan dose if toxicity occurs.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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