Drug interactions
Irinotecan liposomal + Mifepristone
Severity: Major
Irinotecan liposomal and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irinotecan is activated and detoxified by several pathways, including CYP3A4 oxidation to inactive metabolites. Inhibition of CYP3A4 may raise exposure to irinotecan and its active metabolite SN-38, increasing risk of neutropenia and diarrhea.
What this interaction means in plain words
Irinotecan liposomal and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Mifepristone inhibits CYP3A4 and may alter irinotecan metabolism, increasing exposure to active species.
What to do
Avoid strong CYP3A4 inhibitors with irinotecan where possible. If combined, monitor blood counts and diarrhea closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Irinotecan liposomal with Mifepristone?
MediHelp rates the interaction as major. Irinotecan liposomal and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Irinotecan is activated and detoxified by several pathways, including CYP3A4 oxidation to inactive metabolites. Inhibition of CYP3A4 may raise exposure to irinotecan and its active metabolite SN-38, increasing risk of neutropenia and diarrhea.
How serious is the interaction between Irinotecan liposomal and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inhibitors with irinotecan where possible. If combined, monitor blood counts and diarrhea closely.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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