Drug interactions
Irinotecan liposomal + Nicardipine
Severity: Minor
Irinotecan liposomal and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits P-glycoprotein in vitro, which could theoretically raise irinotecan or SN-38 exposure. Clinically meaningful effects with the liposomal formulation are not established, and the liposomal carrier alters its disposition.
What this interaction means in plain words
Irinotecan liposomal and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-glycoprotein inhibition by nicardipine; the clinical relevance for liposomal irinotecan is not established.
What to do
No dose change is needed. Monitor for diarrhea and neutropenia as part of routine irinotecan care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Irinotecan liposomal with Nicardipine?
MediHelp rates the interaction as minor. Irinotecan liposomal and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine inhibits P-glycoprotein in vitro, which could theoretically raise irinotecan or SN-38 exposure. Clinically meaningful effects with the liposomal formulation are not established, and the liposomal carrier alters its disposition.
How serious is the interaction between Irinotecan liposomal and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for diarrhea and neutropenia as part of routine irinotecan care.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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