Drug interactions
Irinotecan liposomal + Ticagrelor
Severity: Minor
Irinotecan liposomal and Ticagrelor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irinotecan is activated and metabolized via CYP3A4, and ticagrelor is a weak CYP3A inhibitor. The effect on irinotecan exposure is likely small and the clinical relevance is uncertain.
What this interaction means in plain words
Irinotecan liposomal and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by ticagrelor may slightly alter irinotecan metabolism.
What to do
Monitor for irinotecan toxicity such as diarrhea and neutropenia. Also watch for bleeding if thrombocytopenia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Irinotecan liposomal with Ticagrelor?
MediHelp rates the interaction as minor. Irinotecan liposomal and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Irinotecan is activated and metabolized via CYP3A4, and ticagrelor is a weak CYP3A inhibitor. The effect on irinotecan exposure is likely small and the clinical relevance is uncertain.
How serious is the interaction between Irinotecan liposomal and Ticagrelor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for irinotecan toxicity such as diarrhea and neutropenia. Also watch for bleeding if thrombocytopenia develops.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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