Drug interactions
Irinotecan liposomal + Verapamil
Severity: Moderate
Irinotecan liposomal and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may raise exposure to irinotecan and its active metabolite SN-38 by inhibiting CYP3A4. This could worsen neutropenia and severe diarrhea.
What this interaction means in plain words
Irinotecan liposomal and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Verapamil inhibits CYP3A4, which metabolizes irinotecan to inactive products, and may inhibit P-gp efflux.
What to do
Choose a non-inhibiting alternative when possible. If combined, monitor blood counts and gastrointestinal toxicity closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Irinotecan liposomal with Verapamil?
MediHelp rates the interaction as moderate. Irinotecan liposomal and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may raise exposure to irinotecan and its active metabolite SN-38 by inhibiting CYP3A4. This could worsen neutropenia and severe diarrhea.
How serious is the interaction between Irinotecan liposomal and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-inhibiting alternative when possible. If combined, monitor blood counts and gastrointestinal toxicity closely.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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