Drug interactions
Isavuconazonium + Isoniazid
Severity: Minor
Isavuconazonium and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is not an established CYP3A4 inducer, so a reduction in isavuconazole levels is not expected. The tuberculosis drug rifampin, not isoniazid, is the clinically important interacting agent for azole antifungals.
What this interaction means in plain words
Isavuconazonium and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Isoniazid belongs to Anti Bacterial.
Why it happens
No established pharmacokinetic mechanism; isoniazid has weak CYP3A4 inhibition at most.
What to do
No dose adjustment is needed. Monitor liver enzymes since both drugs can be hepatotoxic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isavuconazonium and Isoniazid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoniazid
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Isoniazid?
MediHelp rates the interaction as minor. Isavuconazonium and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid is not an established CYP3A4 inducer, so a reduction in isavuconazole levels is not expected. The tuberculosis drug rifampin, not isoniazid, is the clinically important interacting agent for azole antifungals.
How serious is the interaction between Isavuconazonium and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor liver enzymes since both drugs can be hepatotoxic.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
