Drug interactions
Isavuconazonium + Lansoprazole
Severity: Minor
Isavuconazonium and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor, which may raise lansoprazole exposure. Isavuconazole absorption is not meaningfully affected by gastric pH, and the effect on lansoprazole is likely modest.
What this interaction means in plain words
Isavuconazonium and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Isavuconazole inhibits CYP3A4, reducing the metabolism of lansoprazole.
What to do
No routine adjustment is needed; monitor for lansoprazole adverse effects if high doses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Lansoprazole?
MediHelp rates the interaction as minor. Isavuconazonium and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole is a moderate CYP3A4 inhibitor, which may raise lansoprazole exposure. Isavuconazole absorption is not meaningfully affected by gastric pH, and the effect on lansoprazole is likely modest.
How serious is the interaction between Isavuconazonium and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for lansoprazole adverse effects if high doses are used.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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