Drug interactions
Isavuconazonium + Methotrexate
Severity: Minor
Isavuconazonium and Methotrexate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can predispose to infection, methotrexate by immunosuppression and azoles through hepatotoxicity and altered metabolism of other drugs. The pairing is not a well-characterized pharmacokinetic interaction. The antifungal is typically used to treat infection in patients who are already immunocompromised, and hepatotoxicity may be additive.
What this interaction means in plain words
Isavuconazonium and Methotrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Methotrexate belongs to Oncology.
Why it happens
No well-established mechanism; possible additive hepatotoxicity.
What to do
Monitor liver enzymes and blood counts during co-therapy. Adjust methotrexate if hepatotoxicity or cytopenias develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isavuconazonium and Methotrexate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Methotrexate?
MediHelp rates the interaction as minor. Isavuconazonium and Methotrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can predispose to infection, methotrexate by immunosuppression and azoles through hepatotoxicity and altered metabolism of other drugs. The pairing is not a well-characterized pharmacokinetic interaction. The antifungal is typically used to treat infection in patients who are already immunocompromised, and hepatotoxicity may be additive.
How serious is the interaction between Isavuconazonium and Methotrexate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and blood counts during co-therapy. Adjust methotrexate if hepatotoxicity or cytopenias develop.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
