Drug interactions
Isavuconazonium + Olanzapine
Severity: Minor
Isavuconazonium and Olanzapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor, but olanzapine is metabolized mainly by CYP1A2 and UGT1A4, so a clinically important rise in olanzapine levels is unlikely. The legacy direction of effect is not supported.
What this interaction means in plain words
Isavuconazonium and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Olanzapine belongs to Central Nervous System.
Why it happens
Minor contribution of CYP3A4 to olanzapine metabolism, so weak inhibition has limited effect.
What to do
No dose adjustment is usually needed. Monitor for increased sedation or other olanzapine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olanzapine
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Olanzapine?
MediHelp rates the interaction as minor. Isavuconazonium and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole is a moderate CYP3A4 inhibitor, but olanzapine is metabolized mainly by CYP1A2 and UGT1A4, so a clinically important rise in olanzapine levels is unlikely. The legacy direction of effect is not supported.
How serious is the interaction between Isavuconazonium and Olanzapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for increased sedation or other olanzapine adverse effects.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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