Drug interactions
Isavuconazonium + Rabeprazole
Severity: Minor
Isavuconazonium and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rabeprazole is metabolized largely non-enzymatically and is not a clinically meaningful CYP3A4 inhibitor. No clinically significant change in isavuconazole exposure is expected.
What this interaction means in plain words
Isavuconazonium and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
No established mechanism; any CYP3A4 effect of rabeprazole is negligible.
What to do
No dose adjustment is needed. Monitor clinical response to antifungal therapy as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Rabeprazole?
MediHelp rates the interaction as minor. Isavuconazonium and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rabeprazole is metabolized largely non-enzymatically and is not a clinically meaningful CYP3A4 inhibitor. No clinically significant change in isavuconazole exposure is expected.
How serious is the interaction between Isavuconazonium and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor clinical response to antifungal therapy as usual.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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