Drug interactions
Isavuconazonium + Topiramate
Severity: Minor
Isavuconazonium and Topiramate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a CYP3A4 substrate, and strong inducers markedly reduce its levels. Topiramate is only a weak inducer, so any reduction is expected to be small.
What this interaction means in plain words
Isavuconazonium and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Topiramate belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by topiramate may modestly increase isavuconazole metabolism.
What to do
No empirical dose change is required; monitor clinical response to antifungal therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Topiramate
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Topiramate?
MediHelp rates the interaction as minor. Isavuconazonium and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole is a CYP3A4 substrate, and strong inducers markedly reduce its levels. Topiramate is only a weak inducer, so any reduction is expected to be small.
How serious is the interaction between Isavuconazonium and Topiramate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is required; monitor clinical response to antifungal therapy.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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