Drug interactions
Isocarboxazid + Metformin-repaglinide
Severity: Moderate
Isocarboxazid and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nonselective MAO inhibitors such as isocarboxazid can lower blood glucose and may enhance the hypoglycemic effect of antidiabetic drugs. Hypoglycemia may be more frequent or pronounced with the repaglinide component and metformin.
What this interaction means in plain words
Isocarboxazid and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isocarboxazid belongs to Central Nervous System; Metformin-repaglinide belongs to Endocrine.
Why it happens
MAO inhibitors may enhance insulin secretion and sensitivity, producing additive glucose lowering; the exact mechanism is not fully established.
What to do
Monitor blood glucose when starting or stopping isocarboxazid and reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Isocarboxazid and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nonselective MAO inhibitors such as isocarboxazid can lower blood glucose and may enhance the hypoglycemic effect of antidiabetic drugs. Hypoglycemia may be more frequent or pronounced with the repaglinide component and metformin.
How serious is the interaction between Isocarboxazid and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping isocarboxazid and reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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