Drug interactions
Isoflurane + Lefamulin
Severity: Moderate
Isoflurane and Lefamulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin can prolong the QT interval, and isoflurane may add to this effect. Combined use may increase the risk of torsades de pointes, especially with electrolyte abnormalities.
What this interaction means in plain words
Isoflurane and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Lefamulin belongs to Anti Bacterial.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain an ECG and correct potassium and magnesium before anesthesia. Monitor the QTc perioperatively, particularly with other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Isoflurane with Lefamulin?
MediHelp rates the interaction as moderate. Isoflurane and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin can prolong the QT interval, and isoflurane may add to this effect. Combined use may increase the risk of torsades de pointes, especially with electrolyte abnormalities.
How serious is the interaction between Isoflurane and Lefamulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and correct potassium and magnesium before anesthesia. Monitor the QTc perioperatively, particularly with other QT-prolonging drugs.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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