Drug interactions
Isoflurane + Nilotinib
Severity: Major
Isoflurane and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib carries a boxed warning for QT prolongation and sudden death. Isoflurane can add to QT prolongation, which increases risk of torsades de pointes during surgery.
What this interaction means in plain words
Isoflurane and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isoflurane belongs to Central Nervous System; Nilotinib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Review baseline QTc, correct potassium and magnesium, and monitor the ECG continuously. Discuss holding nilotinib perioperatively with the oncologist and avoid other QT-prolonging drugs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isoflurane
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Isoflurane with Nilotinib?
MediHelp rates the interaction as major. Isoflurane and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nilotinib carries a boxed warning for QT prolongation and sudden death. Isoflurane can add to QT prolongation, which increases risk of torsades de pointes during surgery.
How serious is the interaction between Isoflurane and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review baseline QTc, correct potassium and magnesium, and monitor the ECG continuously. Discuss holding nilotinib perioperatively with the oncologist and avoid other QT-prolonging drugs.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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