Drug interactions
Isoflurane + Pasireotide
Severity: Moderate
Isoflurane and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide can cause bradycardia and QT prolongation, and isoflurane may add to QT lengthening. The combination may increase arrhythmia risk during anesthesia.
What this interaction means in plain words
Isoflurane and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Pasireotide belongs to Endocrine.
Why it happens
Additive prolongation of ventricular repolarization (QTc), with pasireotide-related bradycardia.
What to do
Check a baseline ECG and correct electrolytes before anesthesia. Monitor the ECG and heart rate perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isoflurane and Pasireotide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoflurane
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Isoflurane with Pasireotide?
MediHelp rates the interaction as moderate. Isoflurane and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide can cause bradycardia and QT prolongation, and isoflurane may add to QT lengthening. The combination may increase arrhythmia risk during anesthesia.
How serious is the interaction between Isoflurane and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct electrolytes before anesthesia. Monitor the ECG and heart rate perioperatively.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
