Drug interactions
Isoflurane + Pazopanib
Severity: Moderate
Isoflurane and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so giving them together during anesthesia may increase the risk of torsades de pointes. Pazopanib carries a labeled QT warning, and volatile anesthetics add to repolarization delay.
What this interaction means in plain words
Isoflurane and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG perioperatively and avoid other QT-prolonging drugs such as ondansetron.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Isoflurane with Pazopanib?
MediHelp rates the interaction as moderate. Isoflurane and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so giving them together during anesthesia may increase the risk of torsades de pointes. Pazopanib carries a labeled QT warning, and volatile anesthetics add to repolarization delay.
How serious is the interaction between Isoflurane and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG perioperatively and avoid other QT-prolonging drugs such as ondansetron.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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