Drug interactions
Isoflurane + Vandetanib
Severity: Major
Isoflurane and Vandetanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib markedly prolongs the QT interval and has a long half-life. Isoflurane can add further QT prolongation, which increases the risk of torsades de pointes during general anesthesia.
What this interaction means in plain words
Isoflurane and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isoflurane belongs to Central Nervous System; Vandetanib belongs to Oncology.
Why it happens
Additive QT prolongation through delayed cardiac repolarization.
What to do
Obtain an ECG and check electrolytes before anesthesia. Correct potassium, magnesium and calcium, monitor the ECG continuously, and have defibrillation available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isoflurane
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Isoflurane with Vandetanib?
MediHelp rates the interaction as major. Isoflurane and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vandetanib markedly prolongs the QT interval and has a long half-life. Isoflurane can add further QT prolongation, which increases the risk of torsades de pointes during general anesthesia.
How serious is the interaction between Isoflurane and Vandetanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and check electrolytes before anesthesia. Correct potassium, magnesium and calcium, monitor the ECG continuously, and have defibrillation available.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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