Drug interactions
Isoflurane + Zuranolone
Severity: Moderate
Isoflurane and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone is a neuroactive steroid that causes sedation and psychomotor impairment. Isoflurane adds CNS depression, which can lengthen sedation and impair recovery.
What this interaction means in plain words
Isoflurane and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A receptor potentiation by both agents.
What to do
Tell the anesthesia team about recent zuranolone use and titrate anesthetic doses to effect. Monitor sedation and respiration closely through recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Isoflurane with Zuranolone?
MediHelp rates the interaction as moderate. Isoflurane and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone is a neuroactive steroid that causes sedation and psychomotor impairment. Isoflurane adds CNS depression, which can lengthen sedation and impair recovery.
How serious is the interaction between Isoflurane and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about recent zuranolone use and titrate anesthetic doses to effect. Monitor sedation and respiration closely through recovery.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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