Drug interactions
Isometheptene + Linezolid
Severity: Contraindicated
Isometheptene and Linezolid: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isometheptene is an indirect sympathomimetic and linezolid inhibits MAO. Together they may cause marked hypertension and arrhythmia.
What this interaction means in plain words
Isometheptene and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition potentiates sympathomimetic catecholamine release.
What to do
Avoid concurrent use; choose a different migraine therapy during linezolid. Monitor blood pressure and rhythm if exposure occurs.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Isometheptene with Linezolid?
MediHelp rates the interaction as contraindicated. Isometheptene and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isometheptene is an indirect sympathomimetic and linezolid inhibits MAO. Together they may cause marked hypertension and arrhythmia.
How serious is the interaction between Isometheptene and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; choose a different migraine therapy during linezolid. Monitor blood pressure and rhythm if exposure occurs.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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