Drug interactions
Isoniazid + Lemborexant
Severity: Moderate
Isoniazid and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is cleared mainly by CYP3A4, and higher exposure increases next-day somnolence and impaired alertness. Isoniazid may raise lemborexant levels modestly.
What this interaction means in plain words
Isoniazid and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Lemborexant belongs to Central Nervous System.
Why it happens
Isoniazid weakly inhibits CYP3A4, which may reduce lemborexant clearance.
What to do
Use the lowest effective lemborexant dose, such as 5 mg, and warn the patient about daytime drowsiness and driving. Stop or reduce the dose if sedation persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Lemborexant
Frequently asked questions
Can I take Isoniazid with Lemborexant?
MediHelp rates the interaction as moderate. Isoniazid and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lemborexant is cleared mainly by CYP3A4, and higher exposure increases next-day somnolence and impaired alertness. Isoniazid may raise lemborexant levels modestly.
How serious is the interaction between Isoniazid and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lemborexant dose, such as 5 mg, and warn the patient about daytime drowsiness and driving. Stop or reduce the dose if sedation persists.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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