Drug interactions
Isoniazid + Linagliptin-metformin
Severity: Moderate
Isoniazid and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid can impair glucose tolerance and may reduce the effectiveness of antidiabetic therapy. Glycemic control may worsen during treatment.
What this interaction means in plain words
Isoniazid and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Linagliptin-metformin belongs to Endocrine.
Why it happens
Isoniazid may cause hyperglycemia through effects on carbohydrate metabolism; the mechanism is not well established.
What to do
Monitor blood glucose regularly during isoniazid therapy and adjust antidiabetic doses as needed. Watch for hypoglycemia once isoniazid is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Isoniazid and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid can impair glucose tolerance and may reduce the effectiveness of antidiabetic therapy. Glycemic control may worsen during treatment.
How serious is the interaction between Isoniazid and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly during isoniazid therapy and adjust antidiabetic doses as needed. Watch for hypoglycemia once isoniazid is stopped.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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