Drug interactions
Isoniazid + Linezolid
Severity: Moderate
Isoniazid and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid has weak MAO-inhibiting activity, so combining it with linezolid might increase serotonergic and pressor effects. Linezolid is often used with isoniazid in drug-resistant tuberculosis, and clinically significant serotonin syndrome appears uncommon.
What this interaction means in plain words
Isoniazid and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Linezolid belongs to Anti Bacterial.
Why it happens
Additive weak MAO inhibition by isoniazid with linezolid's MAO inhibition.
What to do
Where the regimen requires both, monitor for serotonin toxicity and blood pressure changes. Avoid adding other serotonergic drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Linezolid?
MediHelp rates the interaction as moderate. Isoniazid and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid has weak MAO-inhibiting activity, so combining it with linezolid might increase serotonergic and pressor effects. Linezolid is often used with isoniazid in drug-resistant tuberculosis, and clinically significant serotonin syndrome appears uncommon.
How serious is the interaction between Isoniazid and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where the regimen requires both, monitor for serotonin toxicity and blood pressure changes. Avoid adding other serotonergic drugs.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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