Drug interactions
Isoniazid + Lurbinectedin
Severity: Moderate
Isoniazid and Lurbinectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurbinectedin is metabolized mainly by CYP3A4, and higher exposure increases myelosuppression and hepatotoxicity. Isoniazid, itself hepatotoxic, may modestly raise exposure and adds to liver risk.
What this interaction means in plain words
Isoniazid and Lurbinectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Lurbinectedin belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by isoniazid may raise lurbinectedin levels, with additive hepatotoxicity.
What to do
Monitor blood counts and liver enzymes regularly. Reduce or delay lurbinectedin per labeling if grade 3 or higher toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Isoniazid with Lurbinectedin?
MediHelp rates the interaction as moderate. Isoniazid and Lurbinectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurbinectedin is metabolized mainly by CYP3A4, and higher exposure increases myelosuppression and hepatotoxicity. Isoniazid, itself hepatotoxic, may modestly raise exposure and adds to liver risk.
How serious is the interaction between Isoniazid and Lurbinectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and liver enzymes regularly. Reduce or delay lurbinectedin per labeling if grade 3 or higher toxicity occurs.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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