Drug interactions
Chloramphenicol + Lurbinectedin
Severity: Major
Chloramphenicol and Lurbinectedin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurbinectedin is metabolized mainly by CYP3A4, so inhibitors increase its exposure. This raises the risk of myelosuppression and hepatotoxicity.
What this interaction means in plain words
Chloramphenicol and Lurbinectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Lurbinectedin belongs to Oncology.
Why it happens
Chloramphenicol inhibits CYP3A4, decreasing lurbinectedin clearance.
What to do
Avoid if possible and use an alternative antibiotic. If unavoidable, reduce the lurbinectedin dose by about half and monitor blood counts and liver tests.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Chloramphenicol with Lurbinectedin?
MediHelp rates the interaction as major. Chloramphenicol and Lurbinectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lurbinectedin is metabolized mainly by CYP3A4, so inhibitors increase its exposure. This raises the risk of myelosuppression and hepatotoxicity.
How serious is the interaction between Chloramphenicol and Lurbinectedin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use an alternative antibiotic. If unavoidable, reduce the lurbinectedin dose by about half and monitor blood counts and liver tests.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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