Drug interactions
Aprepitant + Lurbinectedin
Severity: Major
Aprepitant and Lurbinectedin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant may increase lurbinectedin concentrations via CYP3A4 inhibition. This may worsen myelosuppression, hepatotoxicity and other toxicity.
What this interaction means in plain words
Aprepitant and Lurbinectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Lurbinectedin belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4, the main enzyme metabolizing lurbinectedin.
What to do
Avoid moderate CYP3A inhibitors and choose an alternative antiemetic. If unavoidable, monitor blood counts and liver tests and consider lurbinectedin dose reduction per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Aprepitant with Lurbinectedin?
MediHelp rates the interaction as major. Aprepitant and Lurbinectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aprepitant may increase lurbinectedin concentrations via CYP3A4 inhibition. This may worsen myelosuppression, hepatotoxicity and other toxicity.
How serious is the interaction between Aprepitant and Lurbinectedin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid moderate CYP3A inhibitors and choose an alternative antiemetic. If unavoidable, monitor blood counts and liver tests and consider lurbinectedin dose reduction per labeling.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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