Drug interactions
Isoniazid + Memantine-donepezil
Severity: Minor
Isoniazid and Memantine-donepezil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid can inhibit CYP3A4 and other enzymes and may raise donepezil levels slightly. Clinical consequences are expected to be minor and mostly cholinergic in nature.
What this interaction means in plain words
Isoniazid and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Isoniazid inhibits CYP3A4, decreasing donepezil clearance.
What to do
No routine adjustment; monitor for nausea, bradycardia or syncope during isoniazid therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Memantine-donepezil?
MediHelp rates the interaction as minor. Isoniazid and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid can inhibit CYP3A4 and other enzymes and may raise donepezil levels slightly. Clinical consequences are expected to be minor and mostly cholinergic in nature.
How serious is the interaction between Isoniazid and Memantine-donepezil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for nausea, bradycardia or syncope during isoniazid therapy.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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