Drug interactions
Isoniazid + Naloxegol
Severity: Moderate
Isoniazid and Naloxegol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naloxegol is a CYP3A4 and P-glycoprotein substrate, and higher levels can precipitate opioid withdrawal symptoms and gastrointestinal effects. Isoniazid is a weaker CYP3A4 inhibitor than labeled strong inhibitors.
What this interaction means in plain words
Isoniazid and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP3A4 metabolism of naloxegol.
What to do
Monitor for abdominal pain, diarrhea, and opioid withdrawal symptoms. Reduce naloxegol to the lower labeled dose if tolerability issues arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Isoniazid with Naloxegol?
MediHelp rates the interaction as moderate. Isoniazid and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naloxegol is a CYP3A4 and P-glycoprotein substrate, and higher levels can precipitate opioid withdrawal symptoms and gastrointestinal effects. Isoniazid is a weaker CYP3A4 inhibitor than labeled strong inhibitors.
How serious is the interaction between Isoniazid and Naloxegol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for abdominal pain, diarrhea, and opioid withdrawal symptoms. Reduce naloxegol to the lower labeled dose if tolerability issues arise.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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