Drug interactions
Isoniazid + Neratinib
Severity: Moderate
Isoniazid and Neratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neratinib is metabolized mainly by CYP3A4, and higher exposure worsens diarrhea and hepatotoxicity. Isoniazid may modestly increase exposure and is itself hepatotoxic.
What this interaction means in plain words
Isoniazid and Neratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Neratinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by isoniazid may raise neratinib levels, with overlapping hepatotoxicity.
What to do
Monitor liver tests and diarrhea, and use antidiarrheal prophylaxis as per neratinib labeling. Interrupt or reduce neratinib for significant toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Neratinib
- Amiodarone + Neratinib Major
- Amobarbital + Neratinib Major
- Aprepitant + Neratinib Major
- Armodafinil + Neratinib Major
- Bosentan + Neratinib Major
- Carbamazepine + Neratinib Major
Frequently asked questions
Can I take Isoniazid with Neratinib?
MediHelp rates the interaction as moderate. Isoniazid and Neratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Neratinib is metabolized mainly by CYP3A4, and higher exposure worsens diarrhea and hepatotoxicity. Isoniazid may modestly increase exposure and is itself hepatotoxic.
How serious is the interaction between Isoniazid and Neratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver tests and diarrhea, and use antidiarrheal prophylaxis as per neratinib labeling. Interrupt or reduce neratinib for significant toxicity.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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