Drug interactions
Isoniazid + Oliceridine
Severity: Moderate
Isoniazid and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is metabolized by CYP3A4 and CYP2D6, and inhibitors of these enzymes can increase its exposure, with a greater risk of respiratory depression and sedation. Isoniazid inhibits CYP3A4 modestly and has some effect on CYP2D6, so the increase is probably limited.
What this interaction means in plain words
Isoniazid and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Oliceridine belongs to Musculoskeletal.
Why it happens
Isoniazid inhibits CYP3A4 and possibly CYP2D6, decreasing oliceridine metabolism.
What to do
Monitor for sedation and respiratory depression, and lengthen the dosing interval or reduce doses as needed. Reassess opioid requirements if isoniazid is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Isoniazid with Oliceridine?
MediHelp rates the interaction as moderate. Isoniazid and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is metabolized by CYP3A4 and CYP2D6, and inhibitors of these enzymes can increase its exposure, with a greater risk of respiratory depression and sedation. Isoniazid inhibits CYP3A4 modestly and has some effect on CYP2D6, so the increase is probably limited.
How serious is the interaction between Isoniazid and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, and lengthen the dosing interval or reduce doses as needed. Reassess opioid requirements if isoniazid is stopped.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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