Drug interactions
Isoniazid + Pemigatinib
Severity: Moderate
Isoniazid and Pemigatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pemigatinib is cleared mainly by CYP3A4, and inhibitors increase its exposure and toxicity such as hyperphosphatemia and eye disorders. Isoniazid may modestly raise levels.
What this interaction means in plain words
Isoniazid and Pemigatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Pemigatinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by isoniazid may reduce pemigatinib clearance.
What to do
Monitor serum phosphate and ophthalmologic symptoms. Reduce the pemigatinib dose per labeling if adverse reactions occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Pemigatinib
Frequently asked questions
Can I take Isoniazid with Pemigatinib?
MediHelp rates the interaction as moderate. Isoniazid and Pemigatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pemigatinib is cleared mainly by CYP3A4, and inhibitors increase its exposure and toxicity such as hyperphosphatemia and eye disorders. Isoniazid may modestly raise levels.
How serious is the interaction between Isoniazid and Pemigatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum phosphate and ophthalmologic symptoms. Reduce the pemigatinib dose per labeling if adverse reactions occur.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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