Drug interactions
Aprepitant + Pemigatinib
Severity: Major
Aprepitant and Pemigatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pemigatinib is cleared mainly by CYP3A4, so aprepitant can raise its blood levels. This may increase toxicities such as hyperphosphatemia, ocular effects and stomatitis.
What this interaction means in plain words
Aprepitant and Pemigatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Pemigatinib belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4, reducing pemigatinib metabolism.
What to do
Avoid if possible; otherwise reduce the pemigatinib dose per labeling and monitor for adverse effects. Resume the prior dose after the inhibitor has been stopped for about three half-lives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Pemigatinib
Frequently asked questions
Can I take Aprepitant with Pemigatinib?
MediHelp rates the interaction as major. Aprepitant and Pemigatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pemigatinib is cleared mainly by CYP3A4, so aprepitant can raise its blood levels. This may increase toxicities such as hyperphosphatemia, ocular effects and stomatitis.
How serious is the interaction between Aprepitant and Pemigatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the pemigatinib dose per labeling and monitor for adverse effects. Resume the prior dose after the inhibitor has been stopped for about three half-lives.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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