Drug interactions
Amiodarone + Pemigatinib
Severity: Major
Amiodarone and Pemigatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may increase pemigatinib exposure via CYP3A4 inhibition. This may increase toxicities such as hyperphosphatemia, ocular effects and stomatitis.
What this interaction means in plain words
Amiodarone and Pemigatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Pemigatinib belongs to Oncology.
Why it happens
Amiodarone inhibits CYP3A4, decreasing pemigatinib clearance.
What to do
Avoid if possible; otherwise reduce pemigatinib dose per labeling and monitor phosphate and eye symptoms. Return to the prior dose only after the inhibitor is cleared.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Pemigatinib
Frequently asked questions
Can I take Amiodarone with Pemigatinib?
MediHelp rates the interaction as major. Amiodarone and Pemigatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone may increase pemigatinib exposure via CYP3A4 inhibition. This may increase toxicities such as hyperphosphatemia, ocular effects and stomatitis.
How serious is the interaction between Amiodarone and Pemigatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce pemigatinib dose per labeling and monitor phosphate and eye symptoms. Return to the prior dose only after the inhibitor is cleared.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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