Drug interactions
Isoniazid + Pexidartinib
Severity: Major
Isoniazid and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and isoniazid is also a well-known hepatotoxin. Combining them raises the risk of severe hepatic injury, and isoniazid may also modestly raise pexidartinib exposure through CYP3A4 inhibition.
What this interaction means in plain words
Isoniazid and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isoniazid belongs to Anti Bacterial; Pexidartinib belongs to Oncology.
Why it happens
Additive hepatotoxicity, with possible weak CYP3A4 inhibition raising pexidartinib exposure.
What to do
Avoid the combination if possible and choose an alternative to one agent. If unavoidable, monitor liver tests frequently and stop at signs of liver injury.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isoniazid
Other interactions of Pexidartinib
Frequently asked questions
Can I take Isoniazid with Pexidartinib?
MediHelp rates the interaction as major. Isoniazid and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and isoniazid is also a well-known hepatotoxin. Combining them raises the risk of severe hepatic injury, and isoniazid may also modestly raise pexidartinib exposure through CYP3A4 inhibition.
How serious is the interaction between Isoniazid and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and choose an alternative to one agent. If unavoidable, monitor liver tests frequently and stop at signs of liver injury.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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