Drug interactions
Isoniazid + Ramelteon
Severity: Minor
Isoniazid and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid inhibits several CYP enzymes, but its effect on ramelteon is not well documented. Ramelteon is cleared mainly by CYP1A2, with minor CYP3A4 and CYP2C contributions, so a relevant rise in exposure is unlikely.
What this interaction means in plain words
Isoniazid and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Ramelteon belongs to Central Nervous System.
Why it happens
Possible weak CYP inhibition by isoniazid reducing ramelteon metabolism; this is not well established.
What to do
No routine adjustment is needed. Watch for excess daytime drowsiness or dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Isoniazid with Ramelteon?
MediHelp rates the interaction as minor. Isoniazid and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid inhibits several CYP enzymes, but its effect on ramelteon is not well documented. Ramelteon is cleared mainly by CYP1A2, with minor CYP3A4 and CYP2C contributions, so a relevant rise in exposure is unlikely.
How serious is the interaction between Isoniazid and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for excess daytime drowsiness or dizziness.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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