Drug interactions
Isoniazid + Riociguat
Severity: Minor
Isoniazid and Riociguat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is not an established strong ABCG2 inhibitor, so a meaningful increase in riociguat exposure is not documented. Any effect would be theoretical, with hypotension the main concern.
What this interaction means in plain words
Isoniazid and Riociguat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Riociguat belongs to Cardiovascular.
Why it happens
A possible ABCG2 effect has been proposed, but isoniazid is not an established inhibitor and the mechanism is unconfirmed.
What to do
No dose change is needed routinely. Check blood pressure when starting or stopping isoniazid.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Isoniazid with Riociguat?
MediHelp rates the interaction as minor. Isoniazid and Riociguat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid is not an established strong ABCG2 inhibitor, so a meaningful increase in riociguat exposure is not documented. Any effect would be theoretical, with hypotension the main concern.
How serious is the interaction between Isoniazid and Riociguat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed routinely. Check blood pressure when starting or stopping isoniazid.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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