Drug interactions
Isoniazid + Saxagliptin-metformin
Severity: Minor
Isoniazid and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is a weak CYP3A4 inhibitor and is not expected to raise saxagliptin exposure meaningfully, unlike strong inhibitors such as ketoconazole. Isoniazid can also affect glucose control, but no important interaction with this combination is established.
What this interaction means in plain words
Isoniazid and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Weak CYP3A4 inhibition by isoniazid may slightly reduce saxagliptin metabolism.
What to do
No saxagliptin dose limit is required; monitor glucose during isoniazid therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Isoniazid and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid is a weak CYP3A4 inhibitor and is not expected to raise saxagliptin exposure meaningfully, unlike strong inhibitors such as ketoconazole. Isoniazid can also affect glucose control, but no important interaction with this combination is established.
How serious is the interaction between Isoniazid and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No saxagliptin dose limit is required; monitor glucose during isoniazid therapy.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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