Drug interactions
Isoniazid + Sertraline
Severity: Minor
Isoniazid and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid has weak MAO inhibiting properties, so with a serotonergic SSRI such as sertraline there is a theoretical risk of serotonin toxicity. Clinical reports are scarce and most patients tolerate the combination.
What this interaction means in plain words
Isoniazid and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Sertraline belongs to Central Nervous System.
Why it happens
Weak MAO inhibition by isoniazid may add to serotonin reuptake inhibition by sertraline.
What to do
No routine change is needed; educate the patient to report agitation, tremor, diarrhea or fever. Reassess therapy if serotonin toxicity features develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isoniazid and Sertraline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoniazid
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Isoniazid with Sertraline?
MediHelp rates the interaction as minor. Isoniazid and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid has weak MAO inhibiting properties, so with a serotonergic SSRI such as sertraline there is a theoretical risk of serotonin toxicity. Clinical reports are scarce and most patients tolerate the combination.
How serious is the interaction between Isoniazid and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; educate the patient to report agitation, tremor, diarrhea or fever. Reassess therapy if serotonin toxicity features develop.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
