Drug interactions
Isoniazid + Sufentanil
Severity: Moderate
Isoniazid and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is cleared by CYP3A4, and inhibitors can raise its concentrations and prolong opioid effects, including respiratory depression. Isoniazid is a modest CYP3A4 inhibitor, so the effect is probably small but could matter with repeated dosing or infusions.
What this interaction means in plain words
Isoniazid and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Sufentanil belongs to Musculoskeletal.
Why it happens
Isoniazid inhibits CYP3A4, decreasing the clearance of sufentanil.
What to do
Monitor respiratory rate and sedation, and reduce sufentanil doses or extend the interval if excess effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Isoniazid with Sufentanil?
MediHelp rates the interaction as moderate. Isoniazid and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is cleared by CYP3A4, and inhibitors can raise its concentrations and prolong opioid effects, including respiratory depression. Isoniazid is a modest CYP3A4 inhibitor, so the effect is probably small but could matter with repeated dosing or infusions.
How serious is the interaction between Isoniazid and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and sedation, and reduce sufentanil doses or extend the interval if excess effects occur.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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