Drug interactions
Isoniazid + Sumatriptan
Severity: Minor
Isoniazid and Sumatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sumatriptan is cleared mainly by MAO-A, and isoniazid has weak MAO-inhibiting activity, which could theoretically raise sumatriptan exposure. Clinically significant effects are not well documented.
What this interaction means in plain words
Isoniazid and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Sumatriptan belongs to Central Nervous System.
Why it happens
Theoretical weak MAO inhibition by isoniazid reducing sumatriptan metabolism.
What to do
No routine adjustment is needed; counsel the patient to report palpitations, marked agitation or severe headache after dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Isoniazid with Sumatriptan?
MediHelp rates the interaction as minor. Isoniazid and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sumatriptan is cleared mainly by MAO-A, and isoniazid has weak MAO-inhibiting activity, which could theoretically raise sumatriptan exposure. Clinically significant effects are not well documented.
How serious is the interaction between Isoniazid and Sumatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; counsel the patient to report palpitations, marked agitation or severe headache after dosing.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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