Drug interactions
Isoniazid + Umeclidinium-vilanterol
Severity: Minor
Isoniazid and Umeclidinium-vilanterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid has weak CYP3A4 inhibitory activity and might slightly increase vilanterol exposure. Given the low inhaled dose, a clinically meaningful effect is unlikely.
What this interaction means in plain words
Isoniazid and Umeclidinium-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Weak inhibition of CYP3A4 metabolism of vilanterol.
What to do
No routine adjustment is needed. Monitor for beta-agonist effects such as palpitations or tremor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Umeclidinium-vilanterol?
MediHelp rates the interaction as minor. Isoniazid and Umeclidinium-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid has weak CYP3A4 inhibitory activity and might slightly increase vilanterol exposure. Given the low inhaled dose, a clinically meaningful effect is unlikely.
How serious is the interaction between Isoniazid and Umeclidinium-vilanterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for beta-agonist effects such as palpitations or tremor.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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