Drug interactions
Isoniazid + Vardenafil
Severity: Minor
Isoniazid and Vardenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid inhibits some CYP enzymes, including CYP3A4, and may modestly raise vardenafil levels. Clinical consequences are probably limited.
What this interaction means in plain words
Isoniazid and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Vardenafil belongs to Genitourinary.
Why it happens
Isoniazid weakly inhibits CYP3A4, reducing vardenafil metabolism.
What to do
No routine adjustment; counsel patient to report dizziness or symptomatic hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Vardenafil?
MediHelp rates the interaction as minor. Isoniazid and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid inhibits some CYP enzymes, including CYP3A4, and may modestly raise vardenafil levels. Clinical consequences are probably limited.
How serious is the interaction between Isoniazid and Vardenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; counsel patient to report dizziness or symptomatic hypotension.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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