Drug interactions
Isoniazid + Venetoclax
Severity: Moderate
Isoniazid and Venetoclax: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venetoclax is a CYP3A4 substrate, and higher exposure increases the risk of neutropenia and tumor lysis syndrome, especially during ramp-up. Isoniazid is a weak-to-moderate CYP3A4 inhibitor, so the increase is probably smaller than with strong inhibitors.
What this interaction means in plain words
Isoniazid and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Venetoclax belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 metabolism of venetoclax.
What to do
Monitor blood counts and tumor lysis laboratory parameters closely, particularly during ramp-up. Reduce the venetoclax dose per labeling for moderate CYP3A4 inhibitors if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Isoniazid with Venetoclax?
MediHelp rates the interaction as moderate. Isoniazid and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venetoclax is a CYP3A4 substrate, and higher exposure increases the risk of neutropenia and tumor lysis syndrome, especially during ramp-up. Isoniazid is a weak-to-moderate CYP3A4 inhibitor, so the increase is probably smaller than with strong inhibitors.
How serious is the interaction between Isoniazid and Venetoclax?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and tumor lysis laboratory parameters closely, particularly during ramp-up. Reduce the venetoclax dose per labeling for moderate CYP3A4 inhibitors if needed.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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